Estrogen Exposure Rapidly Elevates Nitric Oxide Production in Cerebral Vessels
نویسنده
چکیده
F a c u l t y M e n t o r Diana Krause College of Medicine
منابع مشابه
Estrogen receptor activation of phosphoinositide-3 kinase, akt, and nitric oxide signaling in cerebral blood vessels: rapid and long-term effects.
Estrogen receptor regulation of nitric oxide production by vascular endothelium may involve rapid, membrane-initiated signaling pathways in addition to classic genomic mechanisms. In this study, we demonstrate using intact cerebral blood vessels that 17beta-estradiol rapidly activates endothelial nitric-oxide synthase (eNOS) via a phosphoinositide-3 (PI-3) kinase-dependent pathway. The effect i...
متن کاملAge alters cerebrovascular inflammation and effects of estrogen.
In young adult females, estrogen treatment suppresses the cerebrovascular inflammatory response; this is mediated in part via NF-kappaB, a key regulator of inflammatory genes. To examine whether age modifies effects of estrogen on vascular inflammation in the brain, female rats, 3 and 12 mo of age, were ovariectomized; half were treated with estrogen for 4 wk. Cerebral blood vessels were isolat...
متن کاملRole of Nitric Oxide and ATP-Sensitive K+ Channels in Regulation of Basal Blood Flow and Hypercapnic Vasodilatation of Cerebral Blood Vessels in Rabbit
Background: The mechanisms underlying cerebral hypercapnic vasodilatation are not fully understood. Objective: To investigate the role of nitric oxide (NO) and ATP-sensitive potassium (KATP) channels in basal blood flow regulation and hypercapnia-induced vasodilatation in rabbit cerebral blood vessels. Methods: The change in cerebral blood flow was measured by a laser Doppler flowmeter in 18 Ne...
متن کاملEffect of estrogen on cerebrovascular prostaglandins is amplified in mice with dysfunctional NOS.
Chronic estrogen treatment increases endothelial vasodilator function in cerebral arteries. Endothelial nitric oxide (NO) synthase (eNOS) is a primary target of the hormone, but other endothelial factors may be modulated as well. In light of possible interactions between NO and prostaglandins, we tested the hypothesis that estrogen treatment increases prostanoid-mediated dilation using NOS-defi...
متن کاملMedroxyprogesterone Acetate or Progesterone Cerebral Blood Vessels : Effect Preserved After Concurrent Treatment With Estrogen Increases Endothelial Nitric Oxide Synthase via Estrogen Receptors in Rat
Medroxyprogesterone Acetate or Progesterone Cerebral Blood Vessels : Effect Preserved After Concurrent Treatment With Estrogen Increases Endothelial Nitric Oxide Synthase via Estrogen Receptors in Rat Print ISSN: 0039-2499. Online ISSN: 1524-4628 Copyright © 2002 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas,...
متن کامل